Hailing from Kingston, Jamaica, Sister Nancy emerged as a prominent figure in the reggae scene, following in the footsteps of her brother, Brigadier Jerry. Her career took off in 1980 with the success of her debut track, 'Papa Dean', produced by Winston Riley. Nancy's performances at events like Reggae Sunsplash and A Dee Jay Explosion, where she showcased hits like 'Chalice A Fe Burn' and 'Boom Shacka Lacka', solidified her reputation as a talented artist. Collaborations with producers like Henry 'Junjo' Lawes and artists like Yellowman further propelled her career, earning her international acclaim and opportunities to perform globally.

Alongside her brother Jerry, Nancy frequently graced the stage of the Jahlove Music Sound System, captivating audiences with her dynamic performances. Her debut album, 'One Two', released in 1982, featured standout tracks like 'Aint No Stopping Nancy', 'Bam Bam', and 'Only Woman DJ With Degree', showcasing her versatility as an artist. The siblings' joint performances at venues like Brixton Town Hall in London garnered rave reviews, marking their successful debut in the UK music scene and highlighting Nancy's enduring influence in reggae music.